解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Osteosarcoma (OS) is the most common type of bone cancer. Even with early diagnosis and aggressive treatment, the prognosis for OS is poor. In the present study, we investigated the proliferation and invasion inhibitory effect of apigenin on human OS cells and the possible molecular mechanisms involved. The cell viabi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4022
更新日期:2015-08-01 00:00:00
abstract::MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inh...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4018
更新日期:2015-08-01 00:00:00
abstract::Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell suspensions derived from tumor-draining lymph node (TDLN) an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4064
更新日期:2015-08-01 00:00:00
abstract::Sanguinarine (SAN), an alkaloid isolated from plants of the Papaveraceae family, is a compound with multiple biological activities. In the present study, we explored the anticancer properties of SAN in lung cancer using the human lung adenocarcinoma cell line SPC-A1. Our results revealed that SAN inhibited SPC-A1 cell...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4054
更新日期:2015-08-01 00:00:00
abstract::Accumulation of an excess amount of reactive oxygen species (ROS) can cause hepatotoxicity that may result in liver damage. Therefore, development of anti-oxidative agents is needed for reducing liver toxicity. This study investigated the anti-oxidative and hepatoprotective activity of lithospermic acid, a plant-deriv...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4068
更新日期:2015-08-01 00:00:00
abstract::Endocannabinoids and ceramides have demonstrated growth inhibition, cell death induction and pro-apoptotic activity in cancer research. In the present study, we describe the profiles of two major endocannabinoids, ceramides, free fatty acids and relevant metabolic enzymes in 47 pairs of human colorectal cancer tissues...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3973
更新日期:2015-07-01 00:00:00
abstract::DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) are among the most cytotoxic types of DNA damage. The DNA damage response (DDR) may be a reason for the cancer cell resistance to radiotherapy using IR. Identified as critical upstream mediators of the phosphorylation of ataxia telangiectasia-mutated (...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3980
更新日期:2015-07-01 00:00:00
abstract::Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3991
更新日期:2015-07-01 00:00:00
abstract::Osteosarcoma (OS) has an unfavorable prognosis and tends to metastasize to lung tissue. Although the CXCL12-CXCR4 axis appears to affect progression and metastasis in numerous tumors, its mechanism and downstream pathways in OS remain unclear. We used western blotting and flow cytometry to detect CXCR4 and CXCR7 expre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3992
更新日期:2015-07-01 00:00:00
abstract::Apart from genetic mutations, epigenetic alteration is a common phenomenon that contributes to neoplastic transformation in colorectal cancer. Transcriptional silencing of tumor-suppressor genes without changes in the DNA sequence is explained by the existence of promoter hypermethylation. To test this hypothesis, we ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3993
更新日期:2015-07-01 00:00:00
abstract::Signal transducer and activator of transcription (STAT) 5, including STAT 5a and STAT 5b, was reported to play important roles in the malignant biological behaviors of tumors. However, their roles in gastric cancer, especially for STAT 5b remain unknown. This study aimed to detect the expression of STAT 5b in gastric ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3994
更新日期:2015-07-01 00:00:00
abstract::Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell proliferation, invasion and tube formation in human umbilical vein endot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4000
更新日期:2015-07-01 00:00:00
abstract::Mammary stem cells (MSCs) are the progenitor population for human breast epithelia. MSCs give rise during mammary gland development to estrogen receptor (ER)-negative basal cells and the ER- luminal progenitor (LP) population which maintains ER+ and ER- luminal cells. The MSC population is expanded and tumorigenic in ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4003
更新日期:2015-07-01 00:00:00
abstract::Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3972
更新日期:2015-07-01 00:00:00
abstract::No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...
journal_title:Oncology reports
pub_type: 杂志文章,多中心研究
doi:10.3892/or.2015.3955
更新日期:2015-07-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related mortality in humans. Exploration of the mechanisms underlying the self-renewal and stemness maintenance of cancer stem-like cells (CSLCs) will open new avenues in lung cancer diagnosis and therapy. Here, we isolated and identified a subpopulation of lung cancer stem-l...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3956
更新日期:2015-07-01 00:00:00
abstract::Regulator of G protein signaling 5 (RGS5) belongs to the R4 subfamily of RGS proteins, a family of GTPase activating proteins, which is dynamically regulated in various biological processes including blood pressure regulation, smooth muscle cell pathology, fat metabolism and tumor angiogenesis. Low-expression of RGS5 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3917
更新日期:2015-06-01 00:00:00
abstract::microRNAs (miRNAs) are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC). miR-128-3p was recently reported to be deregulated in several types of cancer. However, the biological function and potential mechanisms of miR-128-3p in HCC remain unknown. In the present study, we found that miR-128-3p...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3936
更新日期:2015-06-01 00:00:00
abstract::The morbidity and mortality of prostate cancer have been increasing recently, and the comprehensive treatment for prostate cancer is unable to achieve satisfactory outcomes. Quercetin is a natural flavonoid compound that has attracted increased interest and attention due to its anticancer activity. In vitro and in viv...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2015.3886
更新日期:2015-06-01 00:00:00
abstract::Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3924
更新日期:2015-06-01 00:00:00
abstract::Inflammation is regarded as one of the major hallmarks of tumors, and has a very close relationship with gastric cancer. Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role in both inflammatory disease and tumors. The present study was designed to explore the effects of IL-33 on the prolif...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3898
更新日期:2015-06-01 00:00:00
abstract::Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3918
更新日期:2015-06-01 00:00:00
abstract::Engrailed 2 (EN2) is a member of the homeobox gene family. Many studies suggest that overexpression of EN2 protein may be associated with tumor development, including bladder cancer (BC). However, to date, the mechanisms of how EN2 functions to promote BC progression remain elusive. The present study introduced RNAi t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3858
更新日期:2015-05-01 00:00:00
abstract::Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiquitin ligases during the process of muscle atrophy of cancer cachexia...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3845
更新日期:2015-05-01 00:00:00
abstract::Colon cancer is the fourth and third most common cancer, respectively in men and women worldwide and its incidence is on the increase. Stress response has been associated with the incidence and development of cancer. The catecholamines (CA), adrenaline (AD) and noradrenaline (NA), are crucial mediators of stress respo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3874
更新日期:2015-05-01 00:00:00
abstract::The clinical applications of Rhizoma paridis in traditional Chinese medicine are well known. However, the therapeutic potential of Rhizoma paridis and its active component such as Paris saponin I (polyphyllin D) and Paris saponin II (PSII) (formosanin C) in cancer treatments have not yet been fully explored. Recent st...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3836
更新日期:2015-05-01 00:00:00
abstract::Annexin A2 (ANXA2) is a well-known calcium-dependent phospholipid binding protein widely distributed in the nucleus, cytoplasm and extracellular surface of various eukaryotic cells. It has been recognized as a pleiotropic protein affecting a wide range of molecular and cellular processes. Dysregulation and abnormal ex...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2015.3837
更新日期:2015-05-01 00:00:00
abstract::Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3866
更新日期:2015-05-01 00:00:00
abstract::Forkhead box F2 transcription factor (FoxF2) has been described to promote organ development, extracellular matrix (ECM) synthesis and epithelial-mesenchymal interaction. Although recent studies reported decreased FoxF2 expression in several types of cancers, indicating its potential role in carcinogenesis, the mechan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3833
更新日期:2015-05-01 00:00:00
abstract::The present study aimed to identify novel histone modification markers in gastric cancer (GC) by chromatin immunoprecipitation microarray (ChIP-chip) analysis and to determine whether these markers were able to discriminate between normal and GC cells. We also tested for correlations with DNA methylation. We probed a ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3824
更新日期:2015-05-01 00:00:00
abstract::9-Oxo-10, 11-dehydroageraphorone (euptox A), a cadenine sesquiterpene, is the main toxin from Eupatorium adenophorum. The aim of the present study was to examine the induction and mechanism of HeLa cell apoptosis by euptox A. The apoptosis‑inducing effect of the euptox A on HeLa cells was examined by MTT assay. The un...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3778
更新日期:2015-04-01 00:00:00
abstract::Bee venom (BV) therapy is a type of alternative medical treatment used to treat various diseases in oriental medicine. The mechanisms underlying the effects of BV remain poorly understood. In the present study, we evaluated the antiviral effect of BV on cervical carcinoma cell lines (CaSki, HeLa, C33A and TC-1). BV tr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3760
更新日期:2015-04-01 00:00:00
abstract::There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature of epigenetic-mediated gene sil...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3802
更新日期:2015-04-01 00:00:00
abstract::High mobility group box-B1 (HMGB1), an autophagy activator, is crucial in tumorigenesis. However, its extracellular role and signaling in gastric cancer remain unclear. Samples were collected from gastric cancer patients and healthy controls. Immunohistochemistry and immunocytochemistry were used to determine the loca...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3782
更新日期:2015-04-01 00:00:00
abstract::Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3792
更新日期:2015-04-01 00:00:00
abstract::This study aimed to investigate the effect of RNA interference (RNAi)-mediated downregulation of the expression of the c-jun gene (a proto-oncogene) on the radiosensitivity of a radioresistant human nasopharyngeal carcinoma cell line (CNE-2R) and to validate its potential as an anticancer target. A lentiviral vector w...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3692
更新日期:2015-03-01 00:00:00
abstract::Prostate cancer is a leading cause of cancer-related death among men. Early diagnosis and treatment are successful against prostate cancer, yet the clinical treatment of advanced prostate cancer remains a challenge. Gemcitabine is used to treat a broad spectrum of solid tumors; however, the clinical response of prosta...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3696
更新日期:2015-03-01 00:00:00
abstract::Deferoxamine (DFO), an iron chelator, has numerous clinical applications for patients presenting with iron overload in regards to the improvement in the quality of life and overall survival. In addition, experimental iron chelators have demonstrated potent anticancer properties. The present study investigated the effe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3676
更新日期:2015-03-01 00:00:00
abstract::Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed chemopreventive effects on colon carcinogenesis, but has nev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3705
更新日期:2015-03-01 00:00:00
abstract::We aimed to examine the relationship between the preoperative GSA index [uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio] calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) sc...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3691
更新日期:2015-03-01 00:00:00